From July 29, the first day of Semester Two, smoking will not be encouraged on campus at all, and will be prohibited within these zones.
Karen Lamont, Director of Human Resources, said most of the feedback to date had been positive.
"A number of staff members and students have told us they're looking forward to going about their business without passing through clouds of second-hand smoke," she said.
"We've also had a number of enquiries about the smoking cessation support we will be providing on campus for staff and students, which is promising."
The Fresh Air Zones will be clearly signposted, with a number of dedicated resources developed to help raise awareness about the new policy. Information will also be hosted on the Murdoch University website and communicated internally.
"We've worked hard to achieve balance with the new policy, taking into account a number of things, including the sheer size of Murdoch's South Street campus," Mrs Lamont said.
"Of course, the health of staff and students is paramount, and the policy will continue to be reviewed based on the feedback we get."
This new initiative complements the existing policy at Peel campus, which has been completely smoke-free since early 2010.
More information is available online here.